Product Description
Snake venom peptides are substances secreted by the snake glands of vipers, which have pharmacological effects such as analgesia, hemostasis, inhibition of thrombosis and antitumor, and have been made into some snake venom preparations for clinical application. However, because snake venom peptides are the most complex type of animal venom, there are at least 20 kinds of active components in each kind of snake venom, including various toxins, enzymes and active peptides, and most of the active components may cause serious toxic side effects in the body, such as cardiotoxicity, neurotoxicity, etc. These toxic side effects are the main reason to limit the application of snake venom preparations in clinical treatment. These toxic side effects are the main reasons limiting the application of snake venom preparations in clinical treatment.
1.Anti cancer
Erpentine peptides show interesting anticancer activity and selectivity, with desintegrins, PLA2 and LAOOs exhibiting a primitive mode of action compared to membrane-disrupting peptides. However, as demonstrated by the premature discontinuation of the phase I clinical trial of VRCTC-310, the size of these peptides makes them susceptible to immune responses. In addition, the low bioavailability of the peptides limits their systemic administration. In the future, studies focused on combining snake venom peptides with complex nanoparticle systems will be more likely to yield drug precursors with selective and controlled delivery.
2.Hemostatic
Snake venom peptides have good analgesic and hemostatic effects, and are good for inhibiting thrombosis. Previously, snake venom components also have better anti-inflammatory effects, thus achieving analgesic and hemostatic effects, and snake venom peptides can regulate cell proliferation and apoptosis, which are combined and usually used in medical treatment to inhibit thrombosis
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