Urolithin is divided into two types: Urolithin A and Urolithin B. Urolithin A is produced by intestinal flora and is a natural metabolite of ellagitannins, a class of compounds found in pomegranates and some other fruits and nuts.
Urolithin A is a potent intestinal metabolite that can restore mitochondria and reverse muscle aging. Research reports have found that a substance called Urolithin A in pomegranates and other fruits may help slow down certain aging processes by improving the function of cell mitochondria; in addition, the intake of this chemical compound has adverse effects on the human body. There is no risk to your health. Research shows that urolithin A stimulates mitochondrial biogenesis in the same way as regular exercise and is the only compound that can re-establish cellular recycling of defective mitochondria.
The urolithin A precursor compound (8.0 g) and AlCl3 (8.83 g) were refluxed overnight in a solution of chlorobenzene (60 ml). After the reaction, the mixture was added to ice water. Chemicalbook can clearly observe the precipitation. The aqueous layer is extracted with ethyl acetate, the organic layer is concentrated under vacuum, and the residue is purified by silica gel column chromatography (10% ethyl acetate/hexane) to obtain the target product.
Urolithin A improves mitochondrial and muscle function, increasing muscle strength and endurance during aging. Oral administration of urolithin A improves mitochondrial function by stimulating a process called mitophagy.
Research reports have found that a substance called Urolithin A in pomegranates and other fruits may help slow down certain aging processes by improving the function of cell mitochondria; in addition, the intake of this chemical compound has adverse effects on the human body. There is no risk to your health. Research shows that urolithin A stimulates mitochondrial biogenesis in the same way as regular exercise and is the only compound that can re-establish cellular recycling of defective mitochondria.
Oral administration of urolithin A improves mitochondrial function by stimulating a process called mitophagy.
After drinking pomegranate juice, compounds called ellagitannins are broken down in the stomach and subsequently converted into urolithin A by intestinal bacteria. Studies have shown that this biotransformation varies greatly between individuals, with some people showing high or low conversion rates, while others with different microbiota compositions are unable to complete this conversion. Therefore, having individuals supplement with products that deliver standardized doses of urolithin A could overcome the natural diversity in the gut flora of the general population.
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