| Customization: | Available |
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| Certification: | USDA Organic/EU Organic/ISO/Kosher/Halal/FDA |
| Assay Method: | TLC |
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Brucea javanica fruit is thought to have anticancer properties in Chinese medicine and its extract has been shown to possess antiproliferative and pro-apoptotic activities on human carcinoma cells. In the present study we demonstrated for the first time that Fructus Bruceae extract exhibited cytotoxic effects on the three pancreatic adenocarcinoma cell lines, PANC-1, SW1990 and CAPAN-1; the effects were comparable to those exhibited by camptothecin in our culture system. In addition, Fructus Bruceae extract induced fragmentation of genomic DNA, as evidenced by Hoechst staining and the cell death detection ELISAPLUS assay. Western blot analysis further showed down-regulation of pro-caspase 3 protein expression, indicating that the observed cytotoxic effects of the extract were associated with induction of apoptosis. These findings are not only significant in the development of traditional Chinese medicine as an alternative treatment for pancreatic cancer, but also in the elucidation of the potential mechanism(s) of Fructus Bruceae extract in cancer therapy.
Basic Information
Botanical Name: Brucea Javanica L.
Part Used: Brucea Javanica Fruit
Specification:4:1 5:1 10:1 20:1
Appearance: Yellow Brown Fine Powder
1).It variously used as analgesics, blood purifiers, bowel and bladder stimulants, or even for poison.
2).It is also believed to be an aid against numbness, rheumatism, spasms, swelling, and trauma, as well as for general bone and circulatory health.1.Medical Purpose
2. Food Additives Food Additives
3.cosmetic grade
| Recommended transportation selections | ||
| By Express | By Air Transportation | By Sea Transportation |
| Suitable for sample order or <50kg Fast: 3-10 days High shipping cost Door to door service |
Suitable for >50kg Fast: 3-7 days Lower than express cost Airport to airport service Professional broker needed |
Suitable for > 300kg Slow: 7-45 days Lowest cost Port to port service Professional broker needed |
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