| CAS No.: | 545-47-1 |
|---|---|
| Formula: | C30H50O |
| EINECS: | 208-889-9 |
| Storage Method: | Normal |
| Shelf Life: | >12 Months |
| Nutrient Composition: | Vitamin |
| Samples: |
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| Customization: |
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Lupinol is a pentacyclic anvil compound that can be extracted from a variety of fruits and vegetables such as strawberries and mangoes, as well as from plants such as Chinese herbs. It has pharmacological effects such as anti-inflammatory, antioxidant, and promotes wound healing, and has shown anti-cancer activity in tumors such as pancreatic cancer, breast cancer, prostate cancer, and melanoma, and is used clinically in the treatment of leukemia, liver cancer, colon cancer, pancreatic cancer, and other diseases.
Certificate of Analysis
| Product Name | Lupeol | ||
| Batch No. | SOST20220827 | Quantity | 50Kg |
| Manufacturing Date | 20220827 | Test Date | 20220830 |
| Expiry Date | 20240826 | Package | 25 Kg/Drum |
| Storage condition | Store with seal at room temperature | ||
| Items | Standards | Results |
| Purity(HPLC) | Lupeol≥98% | 98.6% |
| Appearance | White powder | Conforms |
| Physical characteristics | ||
| Particle-size | NLT100% 80 | Conforms |
| Loss on drying | ≤2.0% | 1.54% |
| Heavy metal | ||
| Total metals | ≤10.0ppm | Conforms |
| Lead | ≤2.0ppm | Conforms |
| Mercury | ≤1.0ppm | Conforms |
| Cadmium | ≤0.5ppm | Conforms |
| Microorganism | ||
| Total number of bacteria | ≤1000cfu/g | Conforms |
| Yeast | ≤100cfu/g | Conforms |
| Escherichia coli | Not included | |
| Salmonella | Not included | Not detected |
| Staphylococcus | Not included | Not detected |
| Conclusions | Qualified | |
1. Anti-tumor effects
(1)Inhibitory effect on melanoma
Lupinol has an inhibitory effect on the growth and induction of differentiation of mouse melanoma.
(2) Inhibitory effect on skin cancer in mice
Lupinol has an inhibitory effect on the development of skin cancer and the expression of its tumor markers.
(3) Inhibitory effect on breast cancer
Lupinol has an inhibitory effect on the growth of breast cancer cells.
(4) Inhibitory and apoptosis-inducing effects on prostate cancer cells
Among endocrine-related tumors, in addition to breast cancer cells, lupinol also has an inhibitory effect on prostate cancer.
(5) Inhibitory and apoptosis-inducing effects on pancreatic cancer
Lupinol has a growth inhibitory effect on pancreatic cancer, and inhibition of the Ras pathway induces apoptosis in pancreatic cancer cells.
(6) Inhibitory effect on hepatocellular carcinoma cells
Lupinol inhibits the self-renewal ability of tumorinitiating cells (TIC) in vitro and in vivo.
(7) Inhibitory effect on leukemia cells
Lupinol has a growth inhibitory and apoptosis-inducing effect on leukemia cells. The inhibitory effect of lupinol on leukemia cells is related to the carbonylation of lupin ring.
(8) Inhibitory effects on other tumors
Lupinol has an inhibitory effect on head and neck tumors. Lupinol has an inhibitory effect on human ovarian cancer cells. 2. Anti-inflammatory effect
3. Antioxidant effect1. It is used in the treatment of leukemia, pancreatic cancer, breast cancer, prostate cancer, melanoma, liver cancer and other tumors.
2. It can be used in the prevention of acute anti-host disease after bone marrow transplantation
3.Lupeol is a pharmacologically active triterpenoid. It has several potential medicinal properties.
4.Lupeol is a triterpenoid, which has strong antioxidant, antimutagenic, anti-inflammatory, and antiarthritic characteristics, and it can be used in pharmaceutical applications.
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