Luotongding

• CAS No.: 10097-84-4
• Formula: C21H25NO4
• Packaging Material: Aluminum Foil Bag/Cardboard barrel
• Storage Method: Normal
• Shelf Life: 24 Months
• Nutrient Composition: Amino Acid
• Resource: Natural
• The content of active substances: 99.5%
• Transport Package: 25 Kg/Carton Outside and Double Food Plastic Bags
• Specification: 98%
• Trademark: SOST
• Origin: China
• Production Capacity: 10000 Kg/Momth

Product Description

Product Description

Rotudine,chemically known as 2,3,9,10- tetramethoxy-5,8,13,13a-tetrahydro-6H-dibenzo[a, g]quinolizine, with molecular formula C21H25NO4, is an antipyretic and analgesic drug, which is mainly used clinically to treat pain of gastric ulcer and duodenal ulcer, menstrual pain, contraction pain after childbirth, nervous insomnia, spasmodic cough, etc.

3.Efficacy of Rotundine

3.1 The product has analgesic, sedative, hypnotic and tranquilizing effects. Its analgesic effect is stronger than that of general antipyretic and analgesic drugs. It has no respiratory depression at therapeutic doses and does not cause smooth muscle spasm in the gastrointestinal tract. It has better effect on chronic persistent pain and visceral dull pain, but less effect on acute acute pain (such as post-surgical pain, traumatic pain, etc.) and advanced cancer pain. It can cause sedation and hypnosis while producing analgesic effect. The mechanism of action of this product is yet to be elucidated and may be related to the blocking of dopamine receptor function in the brain by inhibiting the brainstem reticular up-activation system. Therapeutic doses are not addictive.

3.2 Protective effects on cerebral ischemia-reperfusion injury
 Rotundine significantly prolonged the survival time of cerebral ischemic mice, enhanced the activities of superoxide dismutase and lactate dehydrogenase in brain tissue, and reduced the content of malondialdehyde and nitric oxide, lipid peroxidation products in brain tissue.

Used as antidepressant, API, intermediate.
Certificate of Analysis
Ingredient Name: Rotundine                       Quantity: 2000 Kgs
Batch Number: 20211007                         Date of Manufacture: Oct. 07 , 2021 
Date of Expiration:: Oct. 12 , 2021                      Date of Test : Oct. 10 , 2021

Item                  Standard                          Results              
Appearance   White or almost white crystalline powder          Conforms
Smell &Taste         Odorless                             Conforms
Melting Point         141~144 ºC                             141 ºC              
Optical Rotation       -290°~-300                            -293°
Absorbility            150~160                              153
Identification      (1) Positive reaction
                 (2) Must qualify                      Conforms
Clarity & Colour
of Solution     Between 0.5~1.0, lighter than No.4             Conforms       
Related substances 
 (HPLC)            ≤0.5%                                0.2%
Residue on Ignition     ≤0.1%                               0.08%
Heavy Metals         ≤ 20 ppm                           < 20ppm
Loss on drying          ≤5.0%                             4.4%
ASSAY            98.5%~102 %                          99.5%               

Total Plate Count	≤1000Cfu/g	<10 Cfu/g
Yeast & Mold	≤100Cfu/g	<10 Cfu/g
E.Coli	Negative	Negative
Salmonella	Negative	Negative

Shelf Life : 24 months under the conditions below, no antioxidant used
    Package : 25 kg/carton outside and double food plastic bags inside
                     
QC : Guo Shan                     QA: Feng Li

 

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