| Customization: | Available |
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| CAS No.: | 59-43-8 |
| Formula: | C12H17ClN4OS |
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Vitamin B1 is also known as thiamin. The role of thiamin in the body is to participate in sugar metabolism in the form of carboxylase, a coenzyme of the transhydroxylglyoxalase system, which is a key material basis for substance metabolism and energy metabolism. Vitamin B1 is also involved in the oxidative decarboxylation in the body and is necessary for the metabolism of branched-chain amino acids. In addition, vitamin B1 plays an important role in the promotion of appetite, normal peristalsis of the gastrointestinal tract and the secretion of digestive juices. Vitamin B1 is mainly found in the outer skin and germ of seeds, such as rice bran and bran is rich in content, in yeast is also extremely rich in content. Lean meat, cabbage and celery are also rich in content. The vitamin B1 used is a chemically synthesized product. In the body, vitamin B1 is involved in the catabolism of sugar in the form of coenzyme and has a protective effect on the nervous system; it also promotes gastrointestinal motility and increases appetite.
Vitamin B1 is naturally present in foods such as rice bran, bran, lean meat, peanut rice, etc. Pure products are usually prepared by chemical synthesis. Excess acetamidine hydrochloride is condensed with α-dimethoxy-β-methoxypropionitrile in alkaline (methanol and sodium methanol) medium to 3,6-dimethyl-1,2-dihydro-2,4,5,7-tetraazanonaphthalene, then hydrolyzed at 90-100°C, then opened under alkaline conditions to form 2-methyl-4-amino-5-aminomethylpyrimidine, followed by action with carbon disulfide and ammonia, then condensed with acetic acid-γ Chloro-γ-acetyl propyl ester condensation, then in hydrochloric acid, 75-78 ºC under the hydrolysis and cyclic synthesis of thiamine hydrochloride, and finally neutralized with ammonia, hydrogen peroxide oxidation, acidification of hydrochloric acid to obtain thiamine hydrochloride.
Vitamin B1 is one of the B vitamins, mainly used for the prevention and treatment of vitamin B1 deficiency and its causes of beriberi or Wernickes' encephalopathy, but also for peripheral neuritis, myocarditis, dyspepsia, congestive heart failure and other adjuvant treatment; for vitamin B1 supplementation: including burns, fever, long-term chronic infection patients; malabsorption syndrome with hepatobiliary system diseases (such as alcoholism with Cirrhosis), small intestine diseases (such as celiac disease, persistent diarrhea, etc.), post-gastrectomy, hyperthyroidism and patients on hemodialysis; malnutrition due to prolonged parenteral nutrition or insufficient intake, heavy laborers, and pregnant and lactating women.
Suitable for vitamin B1 deficiency, with the function of maintaining normal glucose metabolism and nerve conduction, also used in the auxiliary treatment of indigestion, neuritis, etc.
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