Sost API Conopeptide Powder

• CAS No.: 996616-33-0
• Formula: C92H139N35O28S6
• Storage Method: Normal
• Shelf Life: >12 Months
• Nutrient Composition: Mineral
• Resource: Natural
• The content of active substances: ＞90%
• Transport Package: 1.1 Kilogram Per Aluminum Foil Bag with One Plast
• Specification: 98.5%-101%
• Trademark: SOST
• Origin: China
• Production Capacity: 10 Kg/Momth

Product Description

Product Description

Conch is a kind of carnivorous tropical Marine mollusk with about 500 species worldwide. Conch is a kind of carnivorous tropical Marine mollusk with about 500 species worldwide. Cone snails can secrete a special kind of peptide venom through their poison tubes, which is used for prey and defense. Venom is mainly composed of a number of small peptides, collectively known as Conotoxin or Cononpeptide. These peptides are generally composed of 10-46 amino acids, rich in disulfide bonds, and have special structures that can specifically act on receptors or ion channels. Due to its small relative molecular weight, novel chemical structure, strong biological activity, and high selectivity of voltage-gated channel target sites, conotoxin can be used as a powerful tool in neuroscience to study ion channels. Cone snails can secrete a special kind of peptide venom through their poison tubes, which is used for prey and defense. Venom is mainly composed of a number of small peptides, collectively known as Conotoxin or Cononpeptide. These peptides are generally composed of 10-46 amino acids, rich in disulfide bonds, and have special structures that can specifically act on receptors or ion channels. Due to its small relative molecular weight, novel chemical structure, strong biological activity, and high selectivity of voltage-gated channel target sites, conotoxin can be used as a powerful tool in neuroscience to study ion channels.

FIGURE 1. The phylogenetic relationship of Conus species. The phylogenetic tree was inferred from the partial sequences of cytochrome oxidase I. Tree building method: PHYLIP Neighbor Joining in the UGENE-1.25.0 program. The Distance matrix model: FB4. Transition/transversion ratio: 2.00. Some species pictures were cited in the literature (Zhang et al., 2019).


FIGURE 2. The annotated conopeptides predicted from transcriptome sequencing. (A) Relationship of the annotated conopeptides predicted by ConoSorter from the Que-1-VD, Que-2-VD, and Que-3-VD. (B) Number of the identified conopeptide precursors previously reported for Conus quercinus.


FIGURE 3. The results of LC-MS/MS analysis. (A) Total ion current traces of the venom ducts of three C. quercinus. Liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) runs using an LTQ Orbitrap Elite System. (B) The Venn diagrams of the identified conopeptides at the protein level from the Que-1-VD, Que-2-VD, and Que-3-VD. (C) The sequence alignment of a novel conopeptide Que-0.1 from the Que-1-VD, Que-2-VD, and Que-3-VD.


FIGURE 4. Phylogenetic tree of signal sequences from three new precursor conopeptides (Supplementary Table 3) and 63 signal sequences. The amino acid sequences were aligned and a guide tree were constructed using the CLUSTALW 2.1. Tree building method: PHYLP Neighbor Joining. The guide tree was decorated using iTOL (http://itol.embl.de/).


4. The role of Conopeptide in skin care products:
4.1.

Conconoid peptide is a biological analog of conconoid toxin. After sequencing and artificial synthesis, it has a very strong muscle relaxation effect and a rapid and immediate anti-wrinkle effect. Conocin effectively relaxes muscles but does not completely paralyze them, retaining 5% of muscle neuromuscular electricity Flow conduction, so it provides a very natural wrinkle-removing effect. Conopeptide is a highly folded peptide with strong penetration, high stability and a specific target for muscle relaxation.


4.2.

Thirty-three subjects were treated with water supplemented with a solution of 3% conotide at a concentration of 20uM
And forehead once, before and 2 hours after the use of a detector to observe the wrinkles, the results showed the use of conoprestin
After a wrinkle can be obvious immediately desalinated, and can maintain 8 hours long; In vitro and in vivo tests showed no cytotoxicity, skin irritation, anaphylaxis or eye irritation.


4.3.

Consnail peptide has now been more and more used in cosmetics skin care, especially as a mild raw material without side effects, used in the field of anti-wrinkle skin care, is a very good anti-wrinkle raw material choice.



Mainly used in medicines(Analgesic and anti-inflammatory drugs).

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