Top Quality CAS 81-25-4 Cholic Acid Powder

• Certification: ISO, USDA Organic/EU Organic/ISO/Kosher/Halal/FDA
• Storage Method: Normal
• Extraction Process: Physical
• Application: Cosmetics, Food, Health Care Products, Medicine
• State: Powder
• Extract Source: cattle, sheep, pigs
• Transport Package: 25 Kg/Carton Outside and Double Food Plastic Bags
• Specification: 99%
• Trademark: SOST
• Origin: China
• Production Capacity: 10000 Kg/Momth

Product Description

Product Description

Cholic acid is a bile acid. Bile acids are produced naturally in the body to aid in digestion of fats and certain nutrients.
People with bile acid disorders are unable to produce cholic acid normally. This can make it harder for the body to absorb nutrients important for health, growth, and body functioning. Abnormal bile acids can also build up in the body and become toxic to the liver.
Cholic acid is used in people with bile acid disorders. This medicine works by normalizing bile acid production in the body.
Cholic acid may also be used for purposes not listed in this medication guide.

The chemical name of Cholic acid is "3,7,12-trihydroxyisovaleric acid". Molecular formula C24H40O5. The molecular weight is 408.59. The orthorhombic crystal system is crystallized from dilute ethanol (monohydrate). The melting point is 198 degrees Celsius (anhydrous), [α] D20+37 degrees Celsius (ethanol, C=0.6). Soluble in alcohol, ether, acetone, chloroform and acetic acid. Exist in the gallbladder of mammals, fish, amphibians and reptiles in the form of taurocholic acid and glycocholic acid. It can form binary eutectics with n-hexadecanol, palmitic acid, stearic acid, stearic acid, octadecenoic acid, docos-13-fumaric acid, etc.

Cholic acid-conjugated prodrugs have liver-targeting effects and improved metabolic stability, and drug design using bile acid as a carrier has gradually become a research hotspot. In recent years, with the in-depth research on cholic acid, the structure-activity relationship between cholic acid as a carrier and transport enzymes and drugs has become more and more clear, thus speeding up the design and synthesis of prodrugs using cholic acid as a carrier, making cholic acid Carrier research has entered a new stage.

Cholic acid is an organic acid with a steroidal structure present in bile. It is one of the components of bile acids. taurine, glycine, etc.). Combined with animal bile, it can emulsify fat and promote fat digestion and absorption. The orthorhombic crystal system is crystallized from dilute ethanol (monohydrate). Soluble in alcohol, ether, acetone, chloroform and acetic acid. Exist in the gallbladder of mammals, fish, amphibians and reptiles in the form of taurocholic acid and glycocholic acid.

Product name	Cholic Acid Powder
Specification	99%
Appearance	Colorless flakes or white crystalline powder
CAS number	81-25-4

 

 

1.Promote the digestion and absorption of lipids

Bile acids contain hydrophilic hydroxyl and carboxyl groups, as well as hydrophobic methyl and hydrocarbon nuclei. at the same time, The steric coordination of hydroxyl and carboxyl groups are both α, so the main configuration of bile acid has both hydrophilicity and hydrophobicity. Tonic promotes lipid emulsification.

 2. Inhibit the precipitation of cholesterol in bile (calculi)

Bile acids can also prevent the formation of gallstones. Cholesterol is hardly soluble in water. When bile drains into the gallbladder for storage, Bile is concentrated in the gallbladder, cholesterol is easy to precipitate, but because bile contains bile acid salts and lecithin, cholesterol can be reduced Disperse to form soluble micelles, not easy to precipitate and form stones.

 3. The physiological functions of bile acids can be summarized as:

influence on bile secretion; influence on lipid absorption; influence on colon function.

1. An organic acid with a steroidal structure that emulsifies fat and facilitates its digestion.
2. Emulsifier.
3. Used in biochemical research and pharmaceutical intermediates. Sodium cholate is a choleretic used to treat cholecystitis, bile deficiency, and intestinal indigestion.
4. Non-denaturing ionic detergent for extracting membrane proteins.
Bile acid as a drug carrier has two applications: one is to use the efficient recovery of bile acids in the small intestine to improve the oral availability of drugs. The second is to use bile acids to be taken up by liver NTCP and reabsorbed by small intestinal cells to improve the liver and intestinal targeting of drugs. In addition, bile acid-utilizing amphiphiles can help improve drug permeability to cell membranes.
5. Use cholic acid to improve the oral availability of drugs.
6. Use cholic acid to improve drug targeting.
7. Use cholic acid to increase the cell membrane permeability of drugs.
 

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