Ritonavir

• CAS No.: 155213-67-5
• Formula: C37H48N6O5S2
• Packaging Material: Aluminum Foil Bag/Cardboard barrel
• Storage Method: Normal
• Shelf Life: 24 Months
• Nutrient Composition: Protein
• Resource: Natural
• The content of active substances: 98.44%
• Transport Package: 25 Kg/Carton Outside and Double Food Plastic Bags
• Specification: 98%
• Trademark: SOST
• Origin: China
• Production Capacity: 100 Kg/Momth

Product Description

Product Description

Ritonavir is an antiretroviral drug used with other drugs to treat HIV/AIDS. this combination therapy is called highly active antiretroviral therapy (HAART). Ritonavir is a protease inhibitor that can be used in combination with other protease inhibitors. However, it is usually used to inhibit the enzyme that metabolizes other protease inhibitors. It can also be used in combination with other drugs to treat hepatitis C. Oral ritonavir tablets are not bioequivalent to capsules because the tablets may result in higher peak plasma concentrations. Common side effects include nausea, vomiting, loss of appetite, diarrhea, and numbness in the hands and feet. Serious side effects include liver problems, pancreatitis, allergic reactions, and cardiac arrhythmias, and serious interactions may occur with many other drugs, including amiodarone and simvastatin. Low doses are considered acceptable for use during pregnancy.




1. Helps with human immunodeficiency virus (HIV) treatment.
This medicine is used along with other HIV medicines to help control HIV infection. It helps reduce the amount of HIV in your body so that your immune system can work better. This will reduce your chance of getting HIV complications (e.g., new infections, cancer) and improve your quality of life. Ritonavir belongs to a group of drugs called protease inhibitors. It increases the levels of other protease inhibitors, which help these drugs work better. Ritonavir does not cure HIV infection. To reduce your risk of spreading HIV disease to others, continue to take all HIV medicines exactly as prescribed by your doctor.

2. Protease inhibitors
Because of the metabolic side effects of ritonavir, lipid-lowering drugs may also be used with protease inhibitors to reduce the risk of cardiovascular disease. Other serious adverse reactions are pancreatitis, diabetes mellitus, renal failure, hypersensitivity reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis relaxation (TEN), hepatotoxicity, leukopenia, and neutropenia.

Antiviral drugs
It was approved by the U.S. FDA to be marketed for antiviral treatment of AIDS in 2000. Although taking the drug brings side effects such as diarrhea, vomiting and high blood lipids, it is still used as the main anti-HIV treatment drug in clinical practice because of its good antiviral effect and high resistance barrier, and the combination consisting of lopinavir and ritonavir is also provided as a free antiviral drug to HIV-infected patients in China. The replication of coronavirus also requires the action of viral. Protease inhibitors against HIV such as lopinavir/ritonavir can have anti-coronaviral effects if they also bind to coronavirus protease and thus inhibit its normal function.

Product name:Ritonavir
Cas number:155213-67-5
Molecular Formula:C37H48N6O5S2
Molecular Weight:720.94

Items	Specifications	Results
Appearance	A white or off white powder	white powder
Identification	IR, HPLC	Conforms
Heavy metals	≤20ppm	Conforms
Water	≤0.5%	0.06%
Residue on ignition	≤0.2%	0.04%
Residual solvents
MTBE	≤500PPM	ND
Methanol	≤500PPM	160ppm
Toluene	≤300PPM	80ppm
Ethyl acetate	≤1000PPM	460ppm
Heptane	≤500PPM	340ppm
Tetrahy drofuran	≤300PPM	130ppm
2-propanol	≤500PPM	120ppm
Ethanol	≤1000PPM	580ppm
Organic Impurities(by HPLC)
Impurity E(RRT=0.36)	≤0.3%	ND
Impurity O(RRT=1.11)	≤0.3%	ND
Impurity T(RRT=2.87)	≤0.2%	ND
Any other impurity	≤0.1%	0.096%
Total Impurities	≤1.0%	0.27%
Assay by HPLC	97.0%-102.0%(on the anhydrous basis)	98.44%
Conclusion	It complies with the USP35 Standard.

  

 

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