Product Description
Tianmain, also known as asparagine, chemically known as 4-hydroxyphenyl-β-D glucopyranoside hemihydrate, API mainly produced in Yunnan Province, China, is a sedative-hypnotic anticonvulsant drug extracted from the dried roots of plants of the genus Orchidaceae, white crystalline powder at room temperature, soluble in water, methanol, ethanol, acetone and hot ethyl acetate, insoluble in ether, asparagine hydrolyzed with bitter almond enzyme. Chemicalbook can get p-hydroxymethylphenidate glycosides. Can restore the balance between cortical excitation and inhibition process imbalance, has a good hypotensive, sedative, hypnotic effect on neurasthenia, insomnia and headache has a certain effect, but also dilate blood vessels, improve myocardial microcirculation, relieve cerebral vascular spasm, increase myocardial nutrient blood flow to improve oxygen supply, is the main drug for the treatment of headache and dizziness, limb numbness, painful convulsions.
1. With neuroprotective properties
The phenols and glycosides in asparagus have neuroprotective effects. For example, asparagine and 4-HBA can reduce neuroinflammation. It reduces microglia activation and stress in cells (especially in the endoplasmic reticulum). Asparagine can also protect the brain from methamphetamine-induced damage to dopaminergic neurons.
2. It can prevent neurodegenerative diseases
In the absence of oxygen, tianma can also protect the brain. For example, during a stroke, aspergillus was able to improve overall tissue damage by 67%. In animal models of ischemic stroke, asparagine and 4-HA can reduce the size of stroke and swelling. It also improved recovery after stroke. Asparagine may be beneficial in Alzheimer's disease (AD) because it helps reduce amyloid plaques in the brain and reduces the neurotoxic effects of these plaques. Tianma may help fight inflammation of the spinal cord. For example, tian mao hook and vine soup (GUD) is commonly used in Chinese medicine to treat spinal cord injuries. In Parkinson's disease (PD) models, asparagine significantly and dose-dependently protects dopaminergic neurons from neurotoxicity to prevent dopamine depletion in the brain.
3. Improve cognition
Asparagine reduces inflammation in the hippocampus and helps increase its size. Asparagine increases brain-derived neurotrophic factor (BDNF) and glial-derived neurotrophic factor (GDNF). Asparagine (combined with electroacupuncture enhancement) was able to reduce Nogo-A expression. Long-term use of asparagine improved learning and memory in memory-impaired rats.
4. may help treat epilepsy
Asparagine may prevent seizures and excitotoxicity in the brain by reducing extracellular glutamate levels.
5. Protect the heart and vascular system
Asparagine may protect the heart from myocardial ischemia-reperfusion injury (MIRI). By helping to maintain normal blood flow in the body, asparagus has a protective effect against strokes and heart attacks. For example, asparagus is used in Chinese medicine to treat dizziness, anemia, low blood pressure, and palpitations. Tianma can also lower high blood pressure and improve blood lipid levels. Asparagine may be effective in protecting against cognitive deficits in patients with vascular dementia. By regulating blood flow, asparagine can help treat migraines and headaches. Asparagine and polysaccharide 2-1 have anticoagulant activity, which inhibits clot formation and reduces the risk of thrombosis.
- Clinical applications, treatment of dizziness, paralysis, epilepsy, stroke and dementia, and some chronic inflammatory diseases. Asparagine exhibits analgesic effects at the spinal cord level in response to spontaneous pain, mechanical and thermal hyperalgesia induced by peripheral inflammation, which is opioid receptor independent and intolerant. This analgesic effect of asparagine is mediated, at least in part, by blocking acid-sensitive ion channels to inhibit spinal synaptic potentiation.
- Pharmacological effects. The application of asparagine or asparagine powder in the preparation of antihepatic fibrosis drugs. For the systematic study of liver histopathological structure of rats, the content of hydroxyproline in rat liver tissue, the oxidative stress response of rat liver tissue and the effect on the degree of liver fibrosis in rats proved that asparagine or asparagine powder has good anti-liver fibrosis activity.
- 3. beauty field.
Asparagus is a traditional herb that has been used in Oriental medicine to treat a wide range of neurological disorders (e.g., paralysis and stroke) and skin problems (e.g., atopic dermatitis and eczema). Asparagus shows a dose-dependent inhibition of melanin synthesis through inhibition of tyrosinase activity. Therefore, asparagus may be an effective natural skin lightening agent for use in the cosmetic industry.
| ANALYSIS ITEM |
SPECIFICATION |
RESULT |
METHOD |
| Appearance |
White powder |
Complies |
Visual |
| Odor |
Characteristic |
Complies |
Organoleptic |
| Assay |
Gastrodin≥98% |
98.23% |
HPLC |
| Loss on Drying |
≤4.0% |
2.1% |
105ºC/3hrs |
| Ash |
≤5.00% |
3.29% |
Ashing Method |
| Particle Size |
100% pass 80 mesh |
Complied |
Complied |
| Residual on Ignition |
<1.0% |
0.27% |
750ºC/5hrs |
| Residual Solvent |
Meet the requirements |
Conforms |
SOP/SA/SOP/SUM/304 |
| Pesticide Residue |
Meet the requirements |
Not detected |
SOP/SA/SOP/SUM/304 |
| Heavy metals |
| Total Heavy Metals |
≤10ppm |
Conforms |
|
| Arsenic |
≤1ppm |
Conforms |
GF AAS |
| Lead |
≤2ppm |
Conforms |
AFS |
| Cadmium |
≤1ppm |
Conforms |
AFS |
| Hygrargyrum |
≤0.1ppm |
Conforms |
AFS |
| Microbiological Tests |
| Total Plate Count |
≤5000cfu/g |
Conforms |
Bacterial culture |
| Total Yeast & Mold |
≤100cfu/g |
Conforms |
Bacterial culture |
| E.Coli |
Negative |
Conforms |
Bacterial culture |
| Salmonella |
Negative |
Conforms |
Bacterial culture |
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